• Introduction
• Vision, Mission and Values
• Funders
• Collaborators
• Staff
• Workshops and Courses
• Research focus Area
• Annual Report 2019
• Annual Report 2018
• Polices and Regulations
• Ongoing Projects
• Publications

As a research group at the National University Biomedical Research Institute (NUBRI), we are conducting whole- genome sequencing of clinically relevant pathogenic micro-organisms using the next generation sequencing platforms. These studies allow us to identify and investigate genetic polymorphisms, including single nucleotide polymorphisms, indels, genomic duplications, and genomic rearrangements that may contribute to phenotypic traits ranging from increased virulence to drug resistance. These also enabled us to identify regions of variation among closely related species that may be used for improved diagnostic. Moreover, we are using whole-genome sequencing to understand the molecular basis of evolution and transmission of infectious diseases, host-pathogen interactions, and to identify novel pathogens. We anticipate that a better understanding of the role of genetic diversity in bacterial infections will result in improved patient care and outcomes. We are complementing our whole genome sequencing efforts with computational methods to examine newly identified polymorphisms at the protein structure level.

Among our interests, are investigating mutations that confer drug resistance and contribute to virulence by utilizing computational tools for homology modelling and small molecule docking.